克罗米酚对男性低促性腺素性功能减退症直接

纽约（华盛顿邮报肥胖版）1月四日报道：据发表在12月再版的《生育与不育》华尔街日报的一项报告指出克罗米胺对大多低促性腺素性新功能与日俱增的年长者病人有利。来自伯明翰北卡罗来纳大学的该报告的第一创作者Scott J. Whitten教授在遵从路透通讯社采访时话说：“原发性或能避免HH病人在遵从不作为性更大和更为昂贵的病患（例如注射促性腺激素类）前进行4个月的克罗米胺实验性病患是有利的。”Whitten教授和同僚研究了克罗米胺对10名HH年长者病人（HH是所致年长者不育的常见因素）是否是适当。报告称克罗米胺病患1年后，4名西蒙(氏)综合征病人中会只有一名病人的精子ppm缩减而全垂体新功能与日俱增症病人的精子忽视病因均并未得到强化。相反，该报告指出3名成年发病的原发性HH年长者病人经过3个月克罗米胺的病患精子ppm有了明显缩减。目前为止该组病人已有两名恢复了生育能力。Whitten教授话说：“除非对克罗米胺病患并未质子化，我们不会因为副作用中止对病人应用于该药物。”再一创作者揭示话说：“因为有条件有限，对HH病人促性腺激素抑制剂和克罗米胺的随机研究难以进行，然而利用多系列的严格选择标准对病人进行分级可能协助全面性的测试克罗米胺恢复年长者低生育能力的适当性。 Male Hypogonadotropic Hypogonadism May Respond to Clomiphene CitrateBy Will Boggs, MDNEW YORK (Reuters Health) Jan 04 - Some men with hypogonadotropic hypogonadism (HH) benefit from treatment with clomiphene citrate, according to a report in the December issue of Fertility and Sterility.Patients with idiopathic or acquired HH "may benefit from a 4-month trial (of clomiphene citrate) before proceeding with more invasive and expensive therapies, such as injectable gonadotropins," lead author Dr. Scott J. Whitten, from University of Alabama at Birmingham, told Reuters Health.Dr. Whitten and colleagues investigated whether 10 men with HH, a rare cause of male infertility, might respond to treatment with clomiphene citrate.Only one of four patients with Kallmann's syndrome experienced an improvement in sperm concentration after 1 year of therapy with clomiphene citrate, the authors report, and no patient with panhypopituitarism experienced a reversal of azoospermia with clomiphene citrate treatment.In contrast, all three men with -onset idiopathic HH experienced significant increases in sperm concentrations and testosterone levels after 3 months of therapy with clomiphene citrate, the report indicates. Two pregnancies he been achieved in this subgroup so far."We did not he any of our patients discontinue the clomiphene because of side effects, only if there was lack of response," Dr. Whitten said."Because this is such a rare condition, additional randomized studies comparing gonadotropins with clomiphene in this subtype of HH patients would be difficult to perform," the authors conclude. "However, larger series using strict inclusion criteria for stratifying patients may be helpful to further examine the success of clomiphene treatment in restoration of this form of male subfertility."Fertil Steril 2006;86:1664-1668.

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编辑： 张靖